If you own one of the best AIO coolers.
One such AIO cooler is this EVGA CLC 280mm RGB LED liquid cooler, which is now on sale on Amazon US for $116.86, 17% ($23.13) cheaper than its original retail price. It's also available on Amazon UK for £117.77 without a discount.
We've known for a long time that liquid cooling achieves better thermal performance from a U than an air cooler, but for many people the risk might seem to outweigh this benefit. After all, doesn't water-cooling a computer involve putting together lots of haphazard pipes and jerry-rigging a pump to push all this through the system and over your delicate components?
Well, no – that's where AIO coolers come in. There's no jerry-rigging involved with an AIO cooler. Simply attach the cooler to your U and motherboard, the radiator to the case, and the fans to the radiator, and you're good to go. (Okay, that might be a slight simplification, but you get the idea: it's no more difficult than installing an air cooler, really).

This one from EVGA specifically has all the bells and whistles you might want. Its 280mm dual-fan radiator should dissipate heat efficiently, and, of course, it has all-important RGB lighting (which can be synced to other EVGA RGB components). EVGA's Flow Control software also allows you to monitor and manage the AIO. If you're looking for an AIO cooler, for this price and with EVGA's stamp of quality you can do a lot worse than the EVGA CLC 280mm RGB.